ABSTRACT
This chapter discusses the pathophysiology and adverse effects of adenoviral vector vaccinations for SARS-CoV-2 and the importance of identifying the true epidemiology of adverse outcomes regarding promoting increased acceptance of COVID-19 vaccinations. This book chapter includes all published studies relating to outcomes after adenoviral-vector vaccination. The findings described show adenoviral vector vaccines are associated with an increased risk of thrombosis, typically with thrombocytopenia. This phenomenon has been termed vaccine-induced thrombotic thrombocytopenia (VITT). The rate of thrombotic adverse effects following vaccination remains lower than the rate of thrombosis following COVID-19 infection. At the current rate of reported severe adverse outcomes, the benefits of vaccination outweigh the risks of remaining unvaccinated regardless of the vaccine vector. © 2021 by Nova Science Publishers, Inc.